August Weismann proposed that genetic changes in somatic cells cannot pass to germ cells and hence to next generations. Nevertheless, evidence is accumulating that some environmental effects can promote heritable changes in the DNA of germ cells, which implies that some somatic influence on germ line is possible. This influence is mostly detrimental and related to the presence of oxidative stress, which induces mutations and epigenetic changes. This effect should be stronger in males due to the particular characteristics of sperm. (...) Here, we propose the hypothesis that females are able to avoid males with oxidatively damaged DNA in the germ line by using oxidative‐dependent (pre‐ and post‐mating) signals. This new hypothesis may shed light on unsolved questions in evolutionary biology, such as the benefits of polyandry, the lek paradox, or the role of sexual selection on the evolution of aging. BioEssays 30:1212–1219, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The Gait Deviation Index is a multivariate measure of overall gait pathology based on 15 gait features derived from three-dimensional kinematic data. GDI aims at providing a comprehensive, easy to interpret, and clinically meaningful metric of overall gait function. It has been used as an outcome measure to study gait in several conditions: cerebral palsy, post-stroke hemiparetic gait, Duchenne muscular dystrophy, and Parkinson’s disease, among others. Nevertheless, its use in population with Spinal Cord Injury has not been studied yet. The (...) aim of the present study was to investigate the applicability of the GDI to SCI through the assessment of the relationship of the GDI with the Walking Index for Spinal Cord Injury II. 3D gait kinematics of 34 patients with incomplete SCI was obtained. Besides, 3D gait kinematics of a sample of 50 healthy volunteers was also gathered with Codamotion motion capture system. A total of 302 and 446 strides were collected. GDI was calculated for each stride and grouped for each WISCI II level. HV data were analyzed as an additional set. Normal distribution for each group was assessed with Kolmogorov-Smirnov tests. Afterward, ANOVA tests were performed between each pair of WISCI II levels to identify differences among groups. The results showed that the GDI was normally distributed across all WISCI II levels in both iSCI and HV groups. Furthermore, our results showed an increasing relationship between the GDI values and WISCI II levels in subjects with iSCI, but only discriminative in WISCI II levels 13, 19, and 20. The index successfully distinguished HV group from all the individuals with iSCI. Findings of this study indicated that the GDI is not an appropriate multivariate walking metric to represent the deviation of gait pattern in adult population with iSCI from a normal gait profile when it is compared with the levels of walking impairment described by the WISCI II. Future work should aim at defining and validating an overall gait index derived from 3D kinematic gait variables appropriate for SCI, additionally taking into account other walking ability outcome measures. (shrink)

O objetivo deste artigo é examinar as relações entre a linguagem e a experiência (a que ela se refere) em Merleau-Ponty. Tento examinar quais as críticas de Meleau-Ponty a uma série de teorias da linguagem que ele considera "naturalizantes". Em seguida, vejo como significações ideiais são possíveis "emergindo" da experiência sensível. Creio ser possível relacionar esses dois patamares mediante o conceito husserliano de Fundierung e a estrutura temporal desse conceito.

Investigando o projeto merleau-pontiano de fundamentação das ciências humanas, notadamente a sociologia e a antropologia, este artigo procura compreender as críticas de Merleau-Ponty à ontologia marxista (de forma genérica) em Les Aventures de la Dialectique, ressaltando a impossibilidade de descrição, desse ponto de vista, das características ontológicas dos fenômenos históricos nos termos de uma totalização dialética da história.

El objetivo de este artículo es explorar las relaciones entre la religión católica y la kultura en Timor-Leste desde una perspectiva histórica y antropológica. Pretendemos mostrar que la relación entre ambas se produce mediante una tensa coexistencia y que no se trata apenas de un sincretismo, resultado de la mezcla de elementos tomados de ambas. Para ello veremos cómo ambos regímenes de creencias se apropian de conceptos ajenos a su liturgia y los resignifican representándolos desde sus propios principios cosmovisvos. Veremos (...) también, mediante un análisis del discurso de un especialista ritual, cómo éste manipula activamente entidades no-humanas de ambos regímenes de creencias, reensamblándolos de un modo que le beneficia, con el objetivo de reforzar su posición en la jerarquía social. Así, mostramos cómo el análisis del enrolamiento de este tipo de entidades en el discurso se hace fundamental para entender los mecanismos de adquisición y distribución de poder en el país. (shrink)

La mujer todavía tiene numerosas barreras para poder acceder al Deporte (Pérez-Ugena, 2020). Esto se debe, tal y como indica Monforte y Úbeda-Colomer (2019) a que los estereotipos de género siguen existiendo en nuestra sociedad. El objetivo de estudio fue analizar los estereotipos de género en la Actividad Física y el Deporte en 51 adolescentes, utilizando para ello variables sociodemográficas y el instrumento de CEGAFD (Granda et al., 2018). Los resultados muestran que, en la mayoría de los ejemplos, se toma (...) como referente el sexo masculino, destacando también, diferencias significativas en la variable de Estereotipos de Género en el Deporte. (shrink)

Utilizando como referencia la Carta política escrita por el general Pedro Alcántara Herrán a Bartolomé Calvo, en el contexto de la guerra civil colombiana de 1859-1862, en este artículo se analizan las relaciones existentes entre la negociación de la paz, la justicia y la regulación de la guerra. Se pretende mostrar que en el siglo xix las iniciativas políticas para evitar, suspender, limitar o terminar la guerra fueron tan abundantes y plurales como los levantamientos y las confrontaciones armadas. Además de (...) presentar la especificidad anómala del caso colombiano, donde históricamente coexisten y se entremezclan los llamados a la guerra con los propósitos de la reconciliación, el artículo rescata, para la actualidad, un documento histórico que sintetiza el lenguaje de la paz, la concordia y la reconciliación en una de las más largas y crueles guerras civiles decimonónicas. (shrink)

8 March, now known as International Women’s Day, is a day for feminist claims where demonstrations are organized in over 150 countries, with the participation of millions of women all around the world. These demonstrations can be viewed as collective rituals and thus focus attention on the processes that facilitate different psychosocial effects. This work aims to explore the mechanisms involved in participation in the demonstrations of 8 March 2020, collective and ritualized feminist actions, and their correlates associated with personal (...) well-being and collective well-being, collective efficacy and collective growth, and behavioral intention to support the fight for women’s rights. To this end, a cross-cultural study was conducted with the participation of 2,854 people from countries in Latin America and Europe, with a retrospective correlational cross-sectional design and a convenience sample. Participants were divided between demonstration participants and non-demonstrators or followers who monitored participants through the media and social networks. Compared with non-demonstrators and with males, female and non-binary gender respondents had greater scores in mechanisms and criterion variables. Further random-effects model meta-analyses revealed that the perceived emotional synchrony was consistently associated with more proximal mechanisms, as well as with criterion variables. Finally, sequential moderation analyses showed that proposed mechanisms successfully mediated the effects of participation on every criterion variable. These results indicate that participation in 8M marches and demonstrations can be analyzed through the literature on collective rituals. As such, collective participation implies positive outcomes both individually and collectively, which are further reinforced through key psychological mechanisms, in line with a Durkheimian approach to collective rituals. (shrink)

Resumen: Durante la Reconquista de Alberto Blest Gana puede ser leída como una novela en donde el secreto y el poder se entrelazan de manera profundamente significativa. Esta interrelación se constituye en el soporte de la narración, en cuyo desarrollo se entretejen los acontecimientos históricos, las intrigas amorosas y la descripción de costumbres sociales. En el despliegue de la novela hallamos inscritas las preocupaciones políticas y éticas de su autor.: Durante la Reconquista by Alberto Blest Gana can be (...) read as a novel in which a secret and power are intertwined in a profoundly significant manner. This interrelationship is constituted in the narrative support, in which the development of historical events, amorous intrigues and social customs are all interwoven. In the unfolding of the novel we can find the inscription of the political and ethical concerns of the author. (shrink)

Social identity is a factor that is associated with well-being and community participation. Some studies have shown that ethnic identity goes along with empowerment, and that interaction between the two leads to greater indices of well-being and community participation. However, other works suggest a contextual circumstance (i.e., perceiving one’s own group as a minority and/or being discriminated) may condition the nature of these relations. By means of a cross-sectional study, we analyzed the relations of social identification (or identity fusion) and (...) collective psychological empowerment with personal well-being, social well-being and community participation in a sample of Basques. A total of 748 Basques participated (63.1% women; ageM= 39.28;SD= 12.13). Individuals who were highly identified or fused with Basque speakers and who were highly empowered showed higher indices of well-being (both personal and social) and of community participation than non-fused individuals with low empowerment. The results also suggest that social identification (or identity fusion) offsets the negative effects of perceiving the group as a linguistic minority. Collective psychological empowerment proved to be an especially relevant factor that needs to continue to be explored. (shrink)

Introducción: el uso de la alimentación enteral en pacientes con demencia resulta un desafío ético-clínico. El objetivo de este artículo es exponer el proceso de validación de un cuestionario para conocer la opinión de los médicos al respecto y sus resultados preliminares. Metodología: se desarrolló un cuestionario anónimo para conocer la opinión de médicos acerca del uso de la alimentación enteral, dirigido a especialistas de cuidados paliativos, geriatría, medicina interna y neurología, de los ámbitos público y privado. Se presentaban allí (...) tres casos clínicos de pacientes con demencia en diferente grado de evolución. Las preguntas abordaban cuatro campos específicos: motivaciones del inicio o suspensión de la alimentación enteral, adecuación terapéutica, eutanasia y toma de decisiones. Resultados: se obtuvo un índice de respuesta del 64 %. El cuestionario resultó una herramienta con validez y fiabilidad aceptables. Los especialistas en cuidados paliativos y geriatría eran más propensos a adecuar el esfuerzo terapéutico y a integrar a la familia en las decisiones. Los profesionales de medicina interna y neurología tendían a ser más invasivos en los tratamientos. Conclusión: los resultados obtenidos permiten recomendar el cuestionario como metodología para valorar la actitud de los profesionales ante las cuestiones bioéticas más relevantes en la atención a pacientes con demencia. (shrink)

O nosso artigo visa o estudo hagiográfico de Santa Quitéria, uma jovem mártir do século II, cuja vida se encontra envolvida em aspectos lendários, ainda pouco estudados. Filha de um nobre pagão, terá nascido na região de Braga, juntamente com mais oito irmãs gémeas. Os primeiros milagres datam do século VIII, altura em que começou a ser venerada como mártir, destino que partilhou com suas irmãs. O martírio é referido, pela primeira vez, no século XII, estando relatado nos Flos Sanctorum (...) de Alonso de Villegas e de Diogo do Rosário e inscrito no Martirológio Romano (22 de Maio). O culto de Santa Quitéria, promovido, particularmente, pelos jesuítas, encontra-se bem alicerçado na devoção popular que a invoca como advogada contra a raiva. A arquidiocese de Braga celebra a sua memória no dia 8 de Junho. Felgueiras não só lhe erigiu um santuário no local onde, supostamente, foi sepultada, como tem Santa Quitéria como padroeira.A iconografia desta nobre donzela romana faz alusão a certos episódios da sua vida e revela o instrumento material do martírio, aspectos que nos propomos analisar bem como fazer referência ao culto e às dificuldades causadas pelas diversas lendas sobre a sua vida. (shrink)

Cultural evolution studies are characterized by the notion that culture evolves accordingly to broadly Darwinian principles. Yet how far the analogy between cultural and genetic evolution should be pushed is open to debate. Here, we examine a recent disagreement that concerns the extent to which cultural transmission should be considered a preservative mechanism allowing selection among different variants, or a transformative process in which individuals recreate variants each time they are transmitted. The latter is associated with the notion of “cultural (...) attraction”. This issue has generated much misunderstanding and confusion. We first clarify the respective positions, noting that there is in fact no substantive incompatibility between cultural attraction and standard cultural evolution approaches, beyond a difference in focus. Whether cultural transmission should be considered a preservative or reconstructive process is ultimately an empirical question, and we examine how both preservative and reconstructive cultural transmission has been studied in recent experimental research in cultural evolution. Finally, we discuss how the relative importance of preservative and reconstructive processes may depend on the granularity of analysis and the domain being studied. (shrink)

The branching-time logic called Peircean by Arthur Prior is considered and given an infinite axiomatization. The axiomatization uses only the standard deduction rules for tense logic.

Cultural evolution researchers use transmission chain experiments to investigate which content is more likely to survive when transmitted from one individual to another. These experiments resemble oral storytelling, wherein individuals need to understand, memorize, and reproduce the content. However, prominent contemporary forms of cultural transmission—think an online sharing—only involve the willingness to transmit the content. Here I present two fully preregistered online experiments that explicitly investigated the differences between these two modalities of transmission. The first experiment (_N_ = 1,080 participants) (...) examined whether negative content, information eliciting disgust, and threat-related information were better transmitted than their neutral counterpart in a traditional transmission chain setup. The second experiment (_N_ = 1,200 participants) used the same material, but participants were asked whether or not they would share the content in two conditions: in a large anonymous social network or with their friends, in their favorite social network. Negative content was both better transmitted in transmission chain experiments and shared more than its neutral counterpart. Threat-related information was successful in transmission chain experiments but not when sharing, and finally, information eliciting disgust was not advantaged in either. Overall, the results present a composite picture, suggesting that the interactions between the specific content and the medium of transmission are important and, possibly, that content biases are stronger when memorization and reproduction are involved in the transmission—as in oral transmission—than when they are not—as in online sharing. Negative content seems to be reliably favored in both modalities of transmission. (shrink)

Gestützt auf die bisher unveröffentlichten Teile des Briefwechsels von Leibniz mit Denis Papin aus der Zeit von 1692 bis 1700 wird in diesem Aufsatz versucht, einige Aspekte der Leibnizschen Dynamik darzulegen. Insbesondere wird der apriorische Beweis der Erhaltung der actio f ormalis im Zusammenhang mit der Diskussion zwischen Leibniz und Papin über die Messung der Kraft bei der horizontalen Bewegung behandelt. Es war Leibniz* Absicht, durch den apriorischen Beweis die Dynamik zu begründen und die Cartesianischen Gesetze der Bewegung zu ersetzen. (...) Papin seinerseits beschränkte sich auf die physikalische Ebene der Gesetze der Mechanik. Im Laufe der Debatte entwickelte Leibniz als Antwort auf Papins Kritik wichtige Argumente über die metaphysische Begründung der Dynamik. Die Begriffe actio f ormalis, inertia naturalis, entelecheia und Geschwindigkeit als quantitas intensiva werden in diesem Zusammenhang von Leibniz gegen Papins Einwände verteidigt. (shrink)

A Political Life is the compelling autobiography of Norberto Bobbio, one of the foremost political thinkers in postwar Italy. In dramatic and lively prose, Bobbio guides us through some of the most significant events of the twentieth century, charting their influence on his life and work. Born in 1909, Norberto Bobbio's early life was marked by the experience of growing up in Mussolini's Italy - an experience that helped to shape his passionate commitment to the anti-fascist cause. As a result (...) of these early experiences, Bobbio has tirelessly emphasized the fundamental, unassailable importance of democratic rights in the modern state. He has been a voice of reason and moderation in a political context where democratic values have often been threatened by extremes. This masterly autobiography traces the development of Bobbio's political thought, providing a penetrating analysis of the changing political landscape of Italy. At the same time, it represents an intimate account of Bobbio's personal experiences, giving a rare insight into the life and work of this distinguished thinker.A Political Life will be of great interest to students and scholars of social and political theory and of Italian politics, as well as to a general readership interested in political biography and contemporary politics. (shrink)

We address the issue of whether, why and under what conditions, quarantine and isolation are morally justified, with a particular focus on measures implemented in the developing world. We argue that the benefits of quarantine and isolation justify some level of coercion or compulsion by the state, but that the state should be able to provide the strongest justification possible for implementing such measures. While a constrained form of consequentialism might provide a justification for such public health interventions, we argue (...) that a stronger justification is provided by a principle of State Enforced Easy Rescue: a state may permissibly compel individuals to engage in activities that entail a small cost to them but a large benefit to others, because individuals have a moral duty of easy rescue to engage in those activities. The principle of State Enforced Easy Rescue gives rise to an Obligation Enforcement Requirement: the state should create the conditions such that submitting to coercive or compulsive measures becomes a fundamental moral duty of individuals, i.e. a duty of easy rescue. When the state can create such conditions, it has the strongest justification possible for implementing coercive or compulsive measures, because individuals have a moral duty to temporarily relinquish the rights that such measures would infringe. Our argument has significant implications for how public health emergencies in the developing world should be tackled. Where isolation and quarantine measures are necessary, states or the international community have a moral obligation to provide certain benefits to those quarantined or isolated. (shrink)

El Estado es un concepto clave en la filosofía jurídico-política de José Ortega y Gasset (Madrid, 1883-1955). Sin embargo, resulta sorprendente que, pese a la importancia que para este autor tenía dicha noción, no haya sido estudiada con la misma profundidad e interés que otras vertientes de su pensamiento. A este respecto, basta repasar las monografías y los artículos publicados hasta la fecha sobre la figura y la obra de Ortega para constatar que, en términos cuantitativos, las investigaciones dedicadas a (...) la idea orteguiana del Estado han sido apenas testimoniales, y desde luego no son tan significativas como las que se han podido dedicar a otros temas o tópicos más conocidos de su pensamiento. Así pues, el presente libro pretende abordar el estudio de la realidad problemática del Estado en su triple dimensión histórica, sociológica y política. De acuerdo con tal propósito, esta monografía se divide en tres partes: en la primera de ellas, se estudian las instituciones políticas de Roma entendidas por Ortega como precedentes ineludibles para la formación histórica del Estado. La segunda parte de la obra versa sobre el Estado concebido como culminación de lo social, es decir, como órgano diferenciado para el ejercicio del poder público, lo cual conduce indefectiblemente hasta la Teoría de los usos sociales. Por último, la tercera parte se centra en el concepto orteguiano de Estado como forma de organización política, explica la relación que mantienen el Estado y nación en su obra, y expone las líneas principales del programa político pensado por Ortega para modernizar, regenerar y europeizar a España. (shrink)

Papers of the international conference "Franz von Baader: Philosophie und Theologie im Spannungsfeld von Technik, Naturwissenschaft und Geschichte" held Oct. 3-6, 2013 in Dresden.

The rapid development of vaccines against COVID‐19 represents a huge achievement, and offers hope of ending the global pandemic. At least three COVID‐19 vaccines have been approved or are about to be approved for distribution in many countries. However, with very limited initial availability, only a minority of the population will be able to receive vaccines this winter. Urgent decisions will have to be made about who should receive priority for access. Current policy in the UK appears to take the (...) view that those who are most vulnerable to COVID‐19 should get the vaccine first. While this is intuitively attractive, we argue that there are other possible values and criteria that need to be considered. These include both intrinsic and instrumental values. The former are numbers of lives saved, years of life saved, quality of the lives saved, quality‐adjusted life‐years (QALYs), and possibly others including age. Instrumental values include protecting healthcare systems and other broader societal interests, which might require prioritizing key worker status and having dependants. The challenge from an ethical point of view is to strike the right balance among these values. It also depends on effectiveness of different vaccines on different population groups and on modelling around cost‐effectiveness of different strategies. It is a mistake to simply assume that prioritizing the most vulnerable is the best strategy. Although that could end up being the best approach, whether it is or not requires careful ethical and empirical analysis. (shrink)

We show that the maximal linear extension theorem for well partial orders is equivalent over RCA0 to ATR0. Analogously, the maximal chain theorem for well partial orders is equivalent to ATR0 over RCA0.

I argue that much philosophical discussion of moral disgust suffers from two ambiguities: first, it is not clear whether arguments for the moral authority of disgust apply to disgust as a consequence of moral evaluations or instead to disgust as a moralizing emotion; second, it is not clear whether the word ‘moral’ is used in a normative or in a descriptive sense. This lack of clarity generates confusion between ‘fittingness’ and ‘appropriateness’ of disgust. I formulate three conditions that arguments for (...) the moral authority of disgust need—but typically fail—to satisfy, in order to avoid (1) circularity, (2) the naturalistic fallacy, and (3) redundancy. These conditions are, respectively, (1) the identification of the direction of the causal relation between disgust and moral evaluation, (2) a demonstration that disgust is ‘fitting’ to morally relevant properties, and (3) a demonstration that disgust is ‘appropriate’ when elicited by these morally relevant properties. I will also suggest that, regardless of whether an argument for the moral authority of disgust can be made, it would be better to avoid the rather obscure term ‘moral disgust’. (shrink)

El artículo analiza el vínculo entre derecho y violencia en Walter Benjamin y Franz Rosenzweig. Primero, se estudia la relación entre Benjamin, Rosenzweig y Carl Schmitt, y, a continuación, la proximidad entre las concepciones benjaminiana y rosenzweiguiana de la historia y de la temporalidad mesiánica, así como la relación entre justicia, derecho y eternidad. Finalmente, se presenta la propuesta derridiana de una deconstrucción de la crítica benjaminiana de la violencia y su antecedente en _La estrella de la redención_.

Insofar as the so-called new theory of reference has come to be acknowleged as the leading theoretical paradigm in semantic research, it has been widely accepted that proper names directly refer to their designation. In advancing some of the most convincing arguments in favour of this view of names, S. Kripke has however left somehow undecided what the role of context is in determining which is the direct referent for a name. According to one interpretation of his thought, context has (...) only an external task in allowing one to simultaneously select a name and a given referent for it. Although this interpretation is the most faithful to Kripke's own intentions, there is another possible interpretation of what he says, according to which context more significantly permits one to determine a given referent at a time for one and the same name1. This different interpretation of the role of context is not marginal for the purpose of semantics, since it generates two distinct theoretical conceptions of what a proper name is. According to the former, the 'idiosyncratic' conception, proper names are individuated (at least) by their form and bearer. According to the latter, the 'linguistic' conception, they are individuated by their morphology only: i.e., by their being (syntactically) unstructured strings of letters. The two conceptions prove to be substantially different when homonyms are called into play. Insofar as both the Greek philosopher and the famous shipowner are called "Aristotle", we have two distinct, albeit homonymous, names for the idiosyncratic conception but only one name (as applied to two distinct individuals) for the linguistic conception2. In what follows, I will first sketch one of the most recent attempts to support for the idiosyncratic view, namely the one which traces back to Kaplan [1990] theory of words, and recall its merits over its cognate idiosyncratic theories. I will then try to give an argument in favour of the linguistic conception, by pointing out how the latter.... (shrink)

_Forgetting Machines. Knowledge Management Evolution in Early Modern Europe_ investigates the evolution of scholarly practices and the transformation of cognitive habits in the early modern age, focussing on the development of note-taking systems and data storage devices.